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A silver Honda Fit and a white Chevrolet Equinox collided on the 600 block just after 8 a.m. on Wednesday, June 12, authorities said.
Both were taken to Paoli Hospital Trauma Center while Route 322/Brandywine Avenue was shut down for more than three hours.
The crash remains under investigation and anyone who witnessed it is asked to call 610-269-0263 or email traffic@downingtown.org.
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